William Nickols 🛠️
William Nickols

PhD Student in Biostatistics at Harvard

Experience

  1. Biostatistics Researcher

    Harvard T.H. Chan School of Public Health

    Dr. Curtis Huttenhower laboratory, Department of Biostatistics, Harvard Chan Center for the Microbiome in Public Health

    • Building computational tools to discover abundance- and prevalence-based microbiome associations (maaslin3, available from BioConductor)
    • Comparing taxonomic assignment tools in environmental microbiomes
    • Creating software for conditional hypergeometric distributions (chyper, available from CRAN)
    • 2021 Program for Research in Science and Engineering (PRISE) fellow
    • 2022 Herchel Smith Undergraduate Science Research Program scholar

    Dr. Daniel Neafsey laboratory, Department of Immunology and Infectious Disease

    • Building computational tools to distinguish new vs. persistent malaria infections in longitudinal genotyping data (DINEMITES, available on GitHub)
    • Collaborating with NIH biostatisticians on monoclonal antibody trials to prevent malaria

    Dr. Douglas Kwon laboratory, Ragon Institute

    • Analyzing >4000 publicly available microbiome samples to determine strain sharing of vaginal species
    • Swab to sequencing whole metagenomic analysis of 400 new samples from a South African cohort
  2. Stat 111 Course Assistant

    Harvard University
    • Prepared original materials for and taught a weekly section to review and expand on class material
    • Created a final review and held a 3-hour review lecture with guided problem solving
    • Hosted weekly office hours
    • In official student evaluations, 44 out of 45 students rated me “Excellent” (the highest rating) overall, and 41 out of 42 students rated my lectures and presentations “Excellent”
    • Original section and final review material are available from GitHub
  3. Stat 139 Course Assistant

    Harvard University
    • Prepared original materials for and taught a weekly section to review and expand on class material
    • Created an example midterm from scratch and held a review session in preparation for the class’s first midterm
    • Held multiple weekly office hours
    • In official student evaluations, 51 out of 55 students rated me “Excellent” (the highest rating) overall, and 47 out of 49 students rated my lectures and presentations “Excellent”
    • Original section and midterm materials and full evaluations including student comments are available from GitHub
  4. Undergraduate Researcher

    Buck Institute for Research on Aging

    Dr. Kai Zhou lab for mitochondria and aging

    • Designed and parameterized computational models of proton movement in mitochondria
    • Developed 3D image analysis methods and statistical workflows for high-throughput protein localization screens
    • Developed ‘omics pipelines for analyzing mitoribosome data
    • Developed 2D and 3D methods for visualizing and quantifying mitoribosome conformation changes
  5. High School Researcher

    University of Texas Southwestern Medical Center

    Dr. Yunsun Nam laboratory, UT Southwestern Green Center for Reproductive Biology

    • Researched DEAD-box helicase binding to RNA G-quadruplexes through the STARS program.
    • Learned PCR, Western blotting, bacterial transformation, Ni-NTA purification, chromatography, EMSA, and crystal tray setup.
    • Presented findings at a UT Southwestern poster session and high school symposium.

Education

  1. PhD, Biostatistics

    Harvard T.H. Chan School of Public Health
    Research focus on developing computational methods for metagenomics, including tools for microbiome association analysis (MaAsLin 3) and longitudinal malaria tracking (DINEMITES). Collaborative work with NIH on monoclonal antibody trial analyses and strain‐sharing studies at the Ragon Institute.
  2. Master of Arts, Statistics

    Harvard Kenneth C. Griffin Graduate School of Arts and Sciences
    Recipient of the Department of Statistics Concurrent Masters Award (2024).
  3. Bachelor of Arts, Statistics & Chemical and Physical Biology, summa cum laude, highest honors

    Harvard College
    Phi Beta Kappa (Junior 24), Undergraduate Research in the Huttenhower lab, Stat 111 Course Assistant, Stat 139 Course Assistant, Cambridge After School Program, Boston Refugee Youth Enrichment program
  4. High School

    Jesuit Dallas
    2020 Valedictorian, student council vice president, medical society president, varsity powerlifting captain
Awards
Phi Beta Kappa
Harvard College ∙ March 2023
Elected as one of 24 juniors into Harvard’s Alpha Iota chapter of Phi Beta Kappa, the oldest academic honor society in the United States, in recognition of exceptional breadth and depth of scholarship.
John Harvard Scholar
Harvard College ∙ November 2023

Recognized for achieving a GPA in the top 5% of the class at the end of each academic year:

  • 2020–2021
  • 2021–2022
  • 2022–2023
    Honorees receive the “John Harvard Scholar” distinction, reflecting sustained academic excellence.
Detur Book Prize
Harvard College ∙ January 2022
Awarded to students demonstrating outstanding academic achievement in their first three semesters.
Recipients are presented with an embossed book of their choice as a keepsake of scholarly distinction.
Jesuit Schools Network Award
Jesuit Dallas ∙ May 2020
Presented annually by the Jesuit Schools Network to one student at each of the 52 Jesuit high schools in the U.S.
Recognizes a “man for others” who exemplifies the ideals of Jesuit education through leadership, service, and character.
National Merit Finalist and Scholar
National Merit Scholarship Corporation ∙ January 2020
Achieved Finalist status in the National Merit Scholarship Program based on PSAT/NMSQT performance.
Subsequently awarded National Merit Scholarship recognition for academic achievement and extracurricular leadership.
Eagle Scout
Boy Scouts of America ∙ August 2016

Attained the rank of Eagle Scout, the highest in the Boy Scouts of America.

  • Planned and led a community service project for Refugee Services of Texas: collected 900+ children’s books, built and installed a bookshelf in the Dallas office.
  • Earned 39 merit badges, including Citizenship in the Community, Personal Management, and Emergency Preparedness.
  • Held leadership roles such as Senior Patrol Leader, Patrol Leader, and Scribe.